Harry P de Koning Selected Research

Trypanosomiasis

1/2022	Nucleoside analogues for the treatment of animal trypanosomiasis.
11/2021	Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites.
12/2020	Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes.
1/2019	Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds.
10/2018	Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
11/2015	Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy.
8/2015	Lowering the pKa of a bisimidazoline lead with halogen atoms results in improved activity and selectivity against Trypanosoma brucei in vitro.
5/2010	Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis.
2/2007	Drugs and drug resistance in African trypanosomiasis.

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Harry P de Koning Research Topics

Disease

18	African Trypanosomiasis (Nagana) 01/2020 - 05/2004
9	Trypanosomiasis 01/2022 - 02/2007
5	Infections 03/2022 - 01/2013
3	Leishmaniasis 11/2021 - 02/2005
3	Trichomonas Infections 11/2021 - 06/2014
3	Schistosomiasis (Bilharziasis) 01/2020 - 01/2019
2	Chagas Disease (American Trypanosomiasis) 01/2020 - 12/2018
2	Neglected Diseases 01/2020 - 01/2019
2	Communicable Diseases (Infectious Diseases) 07/2012 - 05/2003
1	Tuberculosis (Tuberculoses) 01/2020
1	Drug-Related Side Effects and Adverse Reactions 06/2015
1	Starvation 01/2013
1	Parasitic Diseases (Parasitic Disease) 01/2011
1	Body Weight (Weight, Body) 10/2003

Drug/Important Bio-Agent (IBA)

11	Pharmaceutical PreparationsIBA 12/2020 - 10/2003
4	Pentamidine (NebuPent)FDA LinkGeneric 11/2021 - 05/2003
3	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2020 - 01/2011
2	NucleosidesIBA 01/2022 - 03/2007
2	diethylstilbestrol monophosphate (PDES)IBA 01/2020 - 10/2018
2	Cyclic NucleotidesIBA 01/2019 - 01/2011
2	EnzymesIBA 10/2018 - 07/2012
2	DNA (Deoxyribonucleic Acid)IBA 11/2015 - 01/2013
2	Biological ProductsIBA 06/2014 - 05/2010
2	Melarsoprol (Mel B)IBA 03/2013 - 10/2003
2	Arsenicals (Arsenic Compounds)IBA 03/2013 - 08/2008
1	Trypanocidal AgentsIBA 03/2022
1	lipoarabinomannan (LAM)IBA 11/2021
1	Purine NucleosidesIBA 11/2021
1	Antitrichomonal AgentsIBA 11/2021
1	Suramin (Suramin Sodium)IBA 12/2020
1	pyrazoloneIBA 01/2020
1	Praziquantel (Biltricide)FDA Link 01/2020
1	purineIBA 01/2020
1	AnthelminticsIBA 01/2020
1	PyrazolonesIBA 01/2020
1	Cyclic AMP (AMP, Cyclic)IBA 01/2020
1	quinone (benzoquinone)IBA 01/2019
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2019
1	Adenosine Triphosphate (ATP)IBA 01/2019
1	Glycerol (Glycerine)FDA LinkGeneric 01/2019
1	Troleandomycin (TAO)FDA Link 01/2019
1	ascofuranoneIBA 01/2019
1	PurinesIBA 12/2018
1	Kinetoplast DNA (kDNA)IBA 08/2017
1	Mitochondrial DNA (mtDNA)IBA 08/2017
1	VaccinesIBA 05/2016
1	Alkylating AgentsIBA 11/2015
1	Antiprotozoal AgentsIBA 08/2015
1	diphenyl (biphenyl)IBA 08/2015
1	ChitosanIBA 06/2015
1	ImidazolinesIBA 02/2015
1	Metronidazole (Metric)FDA LinkGeneric 01/2015
1	cordycepinIBA 12/2013
1	pyrimidineIBA 01/2013
1	Phosphodiesterase InhibitorsIBA 01/2011
1	N-Glycosyl HydrolasesIBA 05/2010
1	NifurtimoxIBA 02/2007
1	HypoxanthineIBA 02/2005
1	Allopurinol (Remid)FDA LinkGeneric 02/2005
1	diminazene aceturateIBA 05/2004

Therapy/Procedure

5	Therapeutics 06/2015 - 02/2007
2	Drug Therapy (Chemotherapy) 01/2017 - 12/2010
1	Topical Administration 11/2021